Clinical history and incidental abnormality detection in endodontic cone beam computed tomography.

Purpose: To assess the effect of clinical history on incidental abnormality detection, false positive (FP) marks, and diagnostic confidence in endodontic cone beam computed tomography (CBCT) imaging. Approach: A reader performance study using a free-response, factorial study design was undertaken, which accounted for changes in the independent variables: native case type, native case severity, reader type, and reading modality. Twenty-three readers interpreted 26 cases (18 diseased and 8 non-diseased) twice, once with and once without access to clinical history. Each case had at least one incidental abnormality that was not a native endodontic finding. Lesion localization (LL), non-localizations (FPs), and diagnostic confidence (rating 2, 3, or 4: lowest, middle, and highest, respectively) of incidental abnormalities were analyzed. Results: Clinical history increased the detection of incidental abnormalities in non-diseased subtle cases (76 versus 59, p=0.04). Reader experience and monthly CBCT reading volume did not affect incidental abnormality detection. FPs were neither affected by clinical history nor reader characteristics. The highest confidence rating was most often used in each case type when clinical history was available. For this rating, history had significantly greater LLs in subtle diseased (53 versus 41, p=0.03) and non-diseased images (53 versus 33, p=0.02). Conclusions: Clinical history improved the detection of incidental endodontic abnormalities in non-diseased subtle CBCT images and did not affect the number of FP marks. Reader confidence in correctly identified abnormalities was higher with clinical history when disease and non-disease were subtle but was not associated with an improvement in diagnostic performance.

Periapical Radiography versus Cone Beam Computed Tomography in Endodontic Disease Detection: A Free-response, Factorial Study.

AIM: To assess and compare reader performance in interpreting digital periapical (PA) radiography and cone beam computed tomography (CBCT) in endodontic disease detection, using a free-response, factorial model. MATERIALS AND METHODS: A reader performance study of 2 image test sets was undertaken using a factorial, free-response design, accounting for the independent variables: case type, case severity, reader type, and imaging modality. Twenty-two readers interpreted 60 PA and 60 CBCT images divided into 5 categories: diseased-subtle, diseased-moderate, diseased-obvious, nondiseased-subtle, and nondiseased-obvious. Lesion localization fraction, specificity, false positive (FP) marks, and the weighted alternative free-response receiver operating characteristic figure of merit were calculated. RESULTS: CBCT had greater specificity than PA in the obvious nondiseased cases (P = .01) and no significant difference in the subtle nondiseased category. Weighted alternative free-response receiver operating characteristic values were higher for PA than CBCT in the subtle diseased (P = .02) and moderate diseased (P = .01) groups with no significant difference between in the obvious diseased groups. CBCT had higher mean FPs than PA (P < .05) in subtle diseased cases. Mean lesion localization fraction in the moderate diseased group was higher in PA than CBCT (P = .003). No relationships were found between clinical experience and all diagnostic performance measures, except for in the obvious diseased CBCT group, where increasing experience was associated mean FP marks (P = .04). CONCLUSIONS: Reader performance in the detection of endodontic disease is better with PA radiography than CBCT. Clinical experience does not impact upon the accuracy of interpretation of both PA radiography and CBCT.

The Effect of Clinical History on Diagnostic Imaging Interpretation - A Systematic Review.

RATIONALE AND OBJECTIVES: To provide updated information on the effect of clinical history on diagnostic image interpretation and to provide study methodology and design recommendations for future studies assessing the effect of clinical history on diagnostic image performance. MATERIALS AND METHODS: A literature search of Medline, Embase, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted from database inception to July 21, 2020. Studies comparing diagnostic imaging performance with and without clinical history, using observers reading images under both conditions that used an independent reference standard were included. RESULTS: Twenty-two studies met the inclusion criteria, with 15 showing clinical history improved diagnostic performance. One study reported a decrease in diagnostic performance with clinical history and the remaining six studies found no significant change in performance. Two studies used the free response paradigm with both reporting clinical history increased location sensitivity, decreased specificity and had no overall change in diagnostic performance. The disease spectrum of included cases was largely unreported and a balanced reading design was not used in 19 studies. CONCLUSION: Most published studies found that clinical history improved diagnostic performance. More recent studies accounting for abnormality location and multiple abnormalities showed an increase in false positives and no significant change in overall diagnostic performance with clinical history.

Endodontic disease detection: digital periapical radiography versus cone-beam computed tomography-a systematic review.

Purpose: To assess the comparative diagnostic performance of digital periapical (PA) radiography and cone-beam computed tomography (CBCT) imaging on endodontic disease detection and to provide study methodology and design recommendations for future studies comparing the diagnostic performance of imaging modalities on endodontic disease detection. Approach: A search of the Medline, Embase, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials databases was conducted. Studies that compared the performance of CBCT to digital PA radiography for detecting endodontic disease had an independent reference standard determining the presence of endodontic disease and conducted data analysis including either sensitivity, specificity, receiver operating characteristic (ROC) analysis or free response operating characteristic analysis were included. Of the 20,530 identified studies, only 3 fulfilled the inclusion criteria. Results: Most studies assessed for eligibility were excluded due to limitations and biases in study design-15 of 18 studies had no reference standard. Only one retrospective clinical study reported on the diagnostic performance of CBCT and showed a sensitivity of 86% and specificity of 26%. Two cadaver studies reported sensitivity ranging from 60% to 100%, specificity ranging from 79% to 100%, and an area under the ROC curve of 0.943 for CBCT. The reported sensitivity for digital PA radiography ranged from 27% to 60%, specificity was 99%, and the area under the ROC curve was 0.629. Conclusions: There is a lack of quality evidence and insufficient data to compare diagnostic performance of digital PA and CBCT imaging. This emphasizes the need for well-designed studies to inform clinicians about the relative diagnostic performance of these imaging modalities.